The neighborhood is 602.1 acres (2.437 km2) large and bounded by unincorporated Fulton County on all sides, except for the city of Atlanta's NPU P and its Niskey Lake neighborhood on the south. The unincorporated area to the west is organized as the Sandtown community.
Midwest Cascade is located south of Cascade Road, along Regency Center Drive.
The Atlanta City Council voted to annex Midwest Cascade to the City of Atlanta on September 29, 2006.
The NPU went from 1,024 residents in 2000 to 1,770 in 2010, an increase of 72.9%.
The NPU is 96.5% black (2010 census), the highest proportion of any NPU in the city. Small minorities include whites (1.4%) and Hispanics (1.4%).