BCL3

BCL3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1K1A, 1K1B
Dynodwyr
Cyfenwau	BCL3, BCL4, D19S37, B-cell CLL/lymphoma 3, B cell CLL/lymphoma 3, transcription coactivator, BCL3 transcription coactivator
Dynodwyr allanol	OMIM: 109560 HomoloGene: 81738 GeneCards: BCL3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • protein-macromolecule adaptor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • Bcl3-Bcl10 complex • nucleoplasm • perinuclear region of cytoplasm • Bcl3/NF-kappaB2 complex • cnewyllyn cell • cytosol • Cellbilen • midbody • intracellular membrane-bounded organelle • GO:0009327 protein-containing complex Prosesau biolegol • regulation of apoptotic process • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of DNA binding • GO:0009373 regulation of transcription, DNA-templated • T-helper 2 cell differentiation • antimicrobial humoral response • germinal center formation • response to virus • DNA damage response, signal transduction by p53 class mediator • extracellular matrix organization • positive regulation of interferon-gamma production • negative regulation of apoptotic process • spleen development • marginal zone B cell differentiation • positive regulation of translation • transcription, DNA-templated • cellular response to DNA damage stimulus • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • humoral immune response mediated by circulating immunoglobulin • follicular dendritic cell differentiation • defense response to bacterium • T-helper 1 type immune response • GO:0045996 negative regulation of transcription, DNA-templated • I-kappaB kinase/NF-kappaB signaling • response to UV-C • maintenance of protein location in nucleus • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • defense response to protozoan • negative regulation of receptor signaling pathway via JAK-STAT • regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	602	n/a
Ensembl	ENSG00000069399	n/a
UniProt	P20749	n/a
RefSeq (mRNA)	NM_005178	n/a
RefSeq (protein)	NP_005169	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BCL3 yw BCL3 a elwir hefyd yn B-cell CLL/lymphoma 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.32.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BCL3.

• BCL4
• D19S37

• "B-cell CLL/lymphoma 3 promotes glioma cell proliferation and inhibits apoptosis through the oncogenic STAT3 pathway. ". Int J Oncol. 2016. PMID 27748795.
• "Role of Bcl-3 in the development of follicular helper T cells and in the pathogenesis of rheumatoid arthritis. ". Arthritis Rheumatol. 2015. PMID 26138292.
• "Variant of BCL3 gene is strongly associated with five-year survival of non-small-cell lung cancer patients. ". Lung Cancer. 2015. PMID 26122346.
• "BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling. ". Gut. 2016. PMID 26033966.
• "Early diagnostic value of Bcl-3 localization in colorectal cancer.". BMC Cancer. 2015. PMID 25929479.