FHL2

FHL2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X4K, 1X4L, 2D8Z, 2MIU
Dynodwyr
Cyfenwau	FHL2, AAG11, DRAL, FHL-2, SLIM-3, SLIM3, four and a half LIM domains 2
Dynodwyr allanol	OMIM: 602633 HomoloGene: 20372 GeneCards: FHL2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001105 transcription coactivator activity • transcription factor binding • metal ion binding • GO:0001948, GO:0016582 protein binding • androgen receptor binding • identical protein binding Cydrannau o'r gell • cytoplasm • M band • focal adhesion • nucleoplasm • Z discdkac • cnewyllyn cell Prosesau biolegol • androgen receptor signaling pathway • GO:0009373 regulation of transcription, DNA-templated • heart trabecula formation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • osteoblast differentiation • response to hormone • atrial cardiac muscle cell development • GO:0045996 negative regulation of transcription, DNA-templated • ventricular cardiac muscle cell development • regulation of lipid metabolic process • negative regulation of calcineurin-NFAT signaling cascade Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2274	n/a
Ensembl	ENSG00000115641	n/a
UniProt	Q14192	n/a
RefSeq (mRNA)	NM_001039492 NM_001450 NM_201555 NM_201556 NM_201557 NM_001318894 NM_001318895 NM_001318896 NM_001318897 NM_001318898 NM_001318899 NM_001374399	n/a
RefSeq (protein)	NP_001034581 NP_001305823 NP_001305824 NP_001305825 NP_001305826 NP_001305827 NP_001305828 NP_001441 NP_963849 NP_963851 NP_001361328	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FHL2 yw FHL2 a elwir hefyd yn Four and a half LIM domains 2 a Four and a half LIM domains protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q12.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FHL2.

• "Four and a half LIM domains 2 contributes to the development of human tongue squamous cell carcinoma. ". J Mol Histol. 2016. PMID 26759260.
• "Protein-protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease. ". Biochim Biophys Acta. 2016. PMID 26548523.
• "The FHL2 regulation in the transcriptional circuitry of human cancers. ". Gene. 2015. PMID 26211626.
• "LIM-only protein FHL2 critically determines survival and radioresistance of pancreatic cancer cells. ". Cancer Lett. 2015. PMID 25917075.
• "Four and a half LIM domain protein 2 enhances differentiation and mineralization of human dental pulp cells.". J Endod. 2015. PMID 25662359.