KAT5

KAT5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EKO, 2OU2, 4QQG
Dynodwyr
Cyfenwau	KAT5, ESA1, HTATIP, HTATIP1, PLIP, TIP, TIP60, ZC2HC5, cPLA2, lysine acetyltransferase 5, NEDFASB
Dynodwyr allanol	OMIM: 601409 HomoloGene: 100661 GeneCards: KAT5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • GO:0001105 transcription coactivator activity • metal ion binding • histone acetyltransferase activity • GO:0001948, GO:0016582 protein binding • androgen receptor binding • acetyltransferase activity • acyltransferase activity • H4 histone acetyltransferase activity • GO:0031493 histone binding Cydrannau o'r gell • cytoplasm • transcription regulator complex • Piccolo NuA4 histone acetyltransferase complex • nucleoplasm • nucleolus • perinuclear region of cytoplasm • cnewyllyn cell • Swr1 complex • NuA4 histone acetyltransferase complex • histone acetyltransferase complex Prosesau biolegol • response to ionizing radiation • androgen receptor signaling pathway • GO:0009373 regulation of transcription, DNA-templated • cellular response to estradiol stimulus • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • positive regulation of protein acetylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of growth • GO:0022415 viral process • GO:0045996 negative regulation of transcription, DNA-templated • double-strand break repair via nonhomologous end joining • negative regulation of interleukin-2 production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • proteasome-mediated ubiquitin-dependent protein catabolic process • DNA replication • DNA double-strand break processing • beta-catenin-TCF complex assembly • double-strand break repair • histone acetylation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • histone H4 acetylation • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10524	n/a
Ensembl	ENSG00000172977	n/a
UniProt	Q92993	n/a
RefSeq (mRNA)	NM_001206833 NM_006388 NM_182709 NM_182710	n/a
RefSeq (protein)	NP_001193762 NP_006379 NP_874368 NP_874369	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KAT5 yw KAT5 a elwir hefyd yn Lysine acetyltransferase 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KAT5.

• "RVBs are required for assembling a functional TIP60 complex. ". Mol Cell Biol. 2013. PMID 23297341.
• "Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA. ". Oncogene. 2013. PMID 23178490.
• "Targeting cancer using KAT inhibitors to mimic lethal knockouts. ". Biochem Soc Trans. 2016. PMID 27528742.
• "KAT5 (Tip60) is a potential therapeutic target in malignant pleural mesothelioma. ". Int J Oncol. 2016. PMID 26780987.
• "Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-κB pathway.". Clin Exp Metastasis. 2016. PMID 26464124.