MSX2

MSX2
Dynodwyr
Cyfenwau	MSX2, CRS2, FPP, HOX8, MSH, PFM, PFM1, Msh homeobox 2
Dynodwyr allanol	OMIM: 123101 HomoloGene: 1837 GeneCards: MSX2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • DNA binding • GO:0001104 transcription coregulator activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • transcription factor binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell • cytosol • nuclear speck Prosesau biolegol • negative regulation of cell population proliferation • positive regulation of timing of catagen • negative regulation of keratinocyte differentiation • negative regulation of transcription regulatory region DNA binding • embryonic limb morphogenesis • frontal suture morphogenesis • mammary gland epithelium development • BMP signaling pathway involved in heart development • enamel mineralization • ossification • anterior/posterior pattern specification • bone morphogenesis • GO:0009373 regulation of transcription, DNA-templated • cellular response to growth factor stimulus • activation of meiosis • endochondral bone growth • wound healing, spreading of epidermal cells • BMP signaling pathway • embryonic digit morphogenesis • positive regulation of mesenchymal cell apoptotic process • multicellular organism development • embryonic hindlimb morphogenesis • negative regulation of CREB transcription factor activity • outflow tract morphogenesis • bone trabecula formation • wound healing • regulation of apoptotic process • chondrocyte development • osteoblast development • positive regulation of osteoblast differentiation • cranial suture morphogenesis • negative regulation of fat cell differentiation • branching involved in mammary gland duct morphogenesis • outflow tract septum morphogenesis • GO:0045996 negative regulation of transcription, DNA-templated • osteoblast differentiation • epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of BMP signaling pathway • signal transduction involved in regulation of gene expression • cellular response to estradiol stimulus • embryonic forelimb morphogenesis • embryonic nail plate morphogenesis • negative regulation of apoptotic process • cartilage development • stem cell differentiation • odontogenesis • transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • embryonic morphogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4488	n/a
Ensembl	ENSG00000120149	n/a
UniProt	P35548	n/a
RefSeq (mRNA)	NM_002449 NM_001363626	n/a
RefSeq (protein)	NP_002440 NP_001350555	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MSX2 yw MSX2 a elwir hefyd yn Msh homeobox 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q35.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MSX2.

• "Prognostic Relevance and Function of MSX2 in Colorectal Cancer. ". J Diabetes Res. 2017. PMID 28286778.
• "MSX2 Induces Trophoblast Invasion in Human Placenta. ". PLoS One. 2016. PMID 27088357.
• "MSX2 Gene Duplication in a Patient with Eye Development Defects. ". Ophthalmic Genet. 2015. PMID 24666290.
• "Boston type craniosynostosis: report of a second mutation in MSX2. ". Am J Med Genet A. 2013. PMID 23949913.
• "Microduplications upstream of MSX2 are associated with a phenocopy of cleidocranial dysplasia.". J Med Genet. 2012. PMID 22717651.