RUNX1

RUNX1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CMO, 1CO1, 1E50, 1H9D, 1LJM
Dynodwyr
Cyfenwau	RUNX1, AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha, runt related transcription factor 1, RUNX family transcription factor 1
Dynodwyr allanol	OMIM: 151385 HomoloGene: 1331 GeneCards: RUNX1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • calcium ion binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • transcription factor binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • ATP binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • intracellular membrane-bounded organelle • cnewyllyn cell • cytosol • nucleoplasm • core-binding factor complex Prosesau biolegol • peripheral nervous system neuron development • myeloid cell differentiation • GO:0009373 regulation of transcription, DNA-templated • chondrocyte differentiation • ossification • negative regulation of granulocyte differentiation • hematopoietic stem cell proliferation • transcription, DNA-templated • positive regulation of angiogenesis • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of interleukin-2 production • positive regulation of granulocyte differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • regulation of cytokine-mediated signaling pathway • regulation of Wnt signaling pathway • regulation of intracellular estrogen receptor signaling pathway • regulation of regulatory T cell differentiation • regulation of keratinocyte differentiation • regulation of myeloid cell differentiation • regulation of megakaryocyte differentiation • regulation of B cell receptor signaling pathway • regulation of hematopoietic stem cell differentiation • regulation of bicellular tight junction assembly • hemopoiesis • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of CD4-positive, alpha-beta T cell differentiation • positive regulation of CD8-positive, alpha-beta T cell differentiation • negative regulation of gene expression • neuron differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	861	n/a
Ensembl	ENSG00000159216	n/a
UniProt	Q01196	n/a
RefSeq (mRNA)	NM_001001890 NM_001122607 NM_001754	n/a
RefSeq (protein)	NP_001001890 NP_001116079 NP_001745	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RUNX1 yw RUNX1 a elwir hefyd yn Runt related transcription factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 21, band 21q22.12.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RUNX1.

• "RUNX1 Upregulation by Cytotoxic Drugs Promotes Apoptosis. ". Cancer Res. 2017. PMID 29055018.
• "Frequency and Clinicopathologic Features of RUNX1 Mutations in Patients With Acute Myeloid Leukemia Not Otherwise Specified. ". Am J Clin Pathol. 2017. PMID 28927163.
• "H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1alterations. ". Blood. 2017. PMID 28855157.
• "Myeloid neoplasms with germ line RUNX1 mutation. ". Int J Hematol. 2017. PMID 28534116.
• "Recurrent somatic JAK-STAT pathway variants within a RUNX1-mutated pedigree.". Eur J Hum Genet. 2017. PMID 28513614.