SMAD4

SMAD4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DD1, 1G88, 1MR1, 1U7F, 1U7V, 1YGS, 5MEY, 5MEZ, 5MF0
Dynodwyr
Cyfenwau	SMAD4, DPC4, JIP, MADH4, MYHRS, SMAD family member 4
Dynodwyr allanol	OMIM: 600993 HomoloGene: 31310 GeneCards: SMAD4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • protein heterodimerization activity • RNA polymerase II transcription regulatory region sequence-specific DNA binding • metal ion binding • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • I-SMAD binding • collagen binding • GO:0001948, GO:0016582 protein binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • R-SMAD binding • identical protein binding • sulfate binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001104 transcription coregulator activity • molecular function regulator • chromatin binding Cydrannau o'r gell • cnewyllyn cell • cytoplasm • transcription regulator complex • activin responsive factor complex • intracellular anatomical structure • RNA polymerase II transcription regulator complex • nucleoplasm • centrosome • cytosol • SMAD protein complex Prosesau biolegol • negative regulation of cell population proliferation • spermatogenesis • positive regulation of pathway-restricted SMAD protein phosphorylation • positive regulation of luteinizing hormone secretion • regulation of cell population proliferation • cardiac septum development • negative regulation of cell death • regulation of hair follicle development • cellular response to BMP stimulus • epithelial to mesenchymal transition involved in endocardial cushion formation • brainstem development • cell population proliferation • regulation of binding • SMAD protein complex assembly • metanephric mesenchyme morphogenesis • positive regulation of epithelial to mesenchymal transition • GO:0007329 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • branching involved in ureteric bud morphogenesis • GO:0009373 regulation of transcription, DNA-templated • embryonic digit morphogenesis • uterus development • axon guidance • somatic stem cell population maintenance • gastrulation • positive regulation of histone H3-K4 methylation • GO:0045996 negative regulation of transcription, DNA-templated • response to transforming growth factor beta • endothelial cell activation • positive regulation of transforming growth factor beta receptor signaling pathway • single fertilization • transforming growth factor beta receptor signaling pathway • anterior/posterior pattern specification • in utero embryonic development • positive regulation of cell proliferation involved in heart valve morphogenesis • atrioventricular valve formation • GO:0007243 intracellular signal transduction • developmental growth • endoderm development • cellular iron ion homeostasis • kidney development • GO:0007364, GO:0007361, GO:0007358 formation of anatomical boundary • positive regulation of histone H3-K9 acetylation • regulation of transforming growth factor beta2 production • interleukin-6-mediated signaling pathway • GO:1901227 negative regulation of transcription by RNA polymerase II • male gonad development • ovarian follicle development • endocardial cell differentiation • nephrogenic mesenchyme morphogenesis • gastrulation with mouth forming second • female gonad development • SMAD protein signal transduction • response to hypoxia • atrioventricular canal development • mesoderm development • negative regulation of cell growth • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • BMP signaling pathway • tissue morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of SMAD protein signal transduction • somite rostral/caudal axis specification • sebaceous gland development • positive regulation of follicle-stimulating hormone secretion • positive regulation of BMP signaling pathway • neural crest cell differentiation • seminiferous tubule development • female gonad morphogenesis • regulation of transforming growth factor beta receptor signaling pathway • neuron fate commitment • transcription, DNA-templated • outflow tract septum morphogenesis • left ventricular cardiac muscle tissue morphogenesis • negative regulation of cardiac muscle hypertrophy • protein deubiquitination • ventricular septum morphogenesis • negative regulation of ERK1 and ERK2 cascade • negative regulation of cardiac myofibril assembly • protein homotrimerization • pri-miRNA transcription by RNA polymerase II • secondary palate development • anatomical structure morphogenesis • cell differentiation • mesendoderm development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4089	n/a
Ensembl	ENSG00000141646	n/a
UniProt	Q13485	n/a
RefSeq (mRNA)	NM_005359	n/a
RefSeq (protein)	NP_005350	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SMAD4 yw SMAD4 a elwir hefyd yn SMAD family member 4 a Mothers against decapentaplegic homolog 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 18, band 18q21.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SMAD4.

• "Functional characteristics of a novel SMAD4 mutation from thoracic aortic aneurysms (TAA). ". Gene. 2017. PMID 28716708.
• "Prognostic value of loss of heterozygosity and sub-cellular localization of SMAD4 varies with tumor stage in colorectal cancer. ". Oncotarget. 2017. PMID 28423626.
• Myhre Syndrome. 1993. PMID 28406602.
• "DPC4 gene expression in primary pancreatic ductal adenocarcinoma: relationship with CT characteristics. ". Br J Radiol. 2017. PMID 28339284.
• "Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia.". Cancer Med. 2017. PMID 28256094.