THRA

THRA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1NAV, 2H77, 2H79, 3HZF, 3ILZ, 3JZB, 4LNW, 4LNX
Dynodwyr
Cyfenwau	THRA, AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1, thyroid hormone receptor, alpha, thyroid hormone receptor alpha, TRalpha
Dynodwyr allanol	OMIM: 190120 HomoloGene: 37747 GeneCards: THRA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0000975 transcription cis-regulatory region binding • GO:0001948, GO:0016582 protein binding • single-stranded RNA binding • zinc ion binding • chromatin DNA binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • steroid receptor RNA activator RNA binding • transcription factor binding • TBP-class protein binding • steroid hormone receptor activity • DNA binding • protein domain specific binding • sequence-specific DNA binding • metal ion binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • thyroid hormone binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0032403 protein-containing complex binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • nuclear receptor coactivator activity • signaling receptor activity Cydrannau o'r gell • cytoplasm • nucleoplasm • cnewyllyn cell • cytosol • RNA polymerase II transcription regulator complex Prosesau biolegol • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • response to cold • cytoplasmic sequestering of transcription factor • hormone-mediated signaling pathway • regulation of thyroid hormone mediated signaling pathway • thyroid gland development • GO:0009373 regulation of transcription, DNA-templated • ossification • female courtship behavior • cartilage condensation • negative regulation of RNA polymerase II transcription preinitiation complex assembly • type I pneumocyte differentiation • transcription, DNA-templated • steroid hormone mediated signaling pathway • transcription by RNA polymerase II • regulation of lipid catabolic process • regulation of heart contraction • animal organ morphogenesis • positive regulation of female receptivity • learning or memory • regulation of myeloid cell apoptotic process • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription initiation from RNA polymerase II promoter • erythrocyte differentiation • negative regulation of DNA-templated transcription, initiation • positive regulation of myotube differentiation • GO:0045996 negative regulation of transcription, DNA-templated • intracellular receptor signaling pathway • GO:1901227 negative regulation of transcription by RNA polymerase II • thyroid hormone mediated signaling pathway • multicellular organism development • brain development • cell differentiation • response to lipid • positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7067	n/a
Ensembl	ENSG00000126351	n/a
UniProt	P10827	n/a
RefSeq (mRNA)	NM_199334 NM_001190918 NM_001190919 NM_003250	n/a
RefSeq (protein)	NP_001177847 NP_001177848 NP_003241 NP_955366	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn THRA yw THRA a elwir hefyd yn Thyroid hormone receptor, alpha a Thyroid hormone receptor alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn THRA.

• "Thyroid hormone receptor α in breast cancer: prognostic and therapeutic implications. ". Breast Cancer Res Treat. 2015. PMID 25542270.
• "Translating thyroid hormone effects into clinical practice: the relevance of thyroid hormone receptor α1 in cardiac repair. ". Heart Fail Rev. 2015. PMID 25501869.
• "Diverse Genotypes and Phenotypes of Three Novel Thyroid Hormone Receptor-α Mutations. ". J Clin Endocrinol Metab. 2016. PMID 27144938.
• "TRα receptor mutations extend the spectrum of syndromes of reduced sensitivity to thyroid hormone. ". Presse Med. 2015. PMID 26585273.
• "Thyroid hormone resistance syndrome due to mutations in the thyroid hormone receptor α gene (THRA).". J Med Genet. 2015. PMID 25670821.