Retinoid receptor
Nuclear receptors that bind to retinoids
Retinoid receptors are type II nuclear receptors (a class of proteins) that bind to retinoids. When bound to a retinoid, they act as transcription factors, altering the expression of genes with corresponding response elements.
Subtypes include:
References
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(1) Basic domains |
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(1.1) Basic leucine zipper (bZIP) | |
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(1.2) Basic helix-loop-helix (bHLH) | Group A | |
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Group B | |
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Group C bHLH-PAS | |
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Group D | |
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Group E | |
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Group F bHLH-COE | |
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(1.3) bHLH-ZIP | |
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(1.4) NF-1 | |
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(1.5) RF-X | |
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(1.6) Basic helix-span-helix (bHSH) | |
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(2) Zinc finger DNA-binding domains |
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(2.1) Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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RARTooltip Retinoic acid receptor |
- Antagonists: BMS-195614
- BMS-493
- CD-2665
- ER-50891
- LE-135
- MM-11253
- Retinoic acid metabolism inhibitors: Liarozole
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RXRTooltip Retinoid X receptor |
- Antagonists: HX-531
- HX-630
- LG-100754
- PA-452
- UVI-3003
- HX-603
- LE135 (RAR beta selective)
- LE-540
- CD3254
- PA-451
- PA-452
- Rhein
- HX-711
- 6-(N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino)nicotinic acid
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