MBD1

MBD1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IG4, 1D9N, 4D4W
Dynodwyr
Cyfenwau	MBD1, CXXC3, PCM1, RFT, methyl-CpG binding domain protein 1
Dynodwyr allanol	OMIM: 156535 HomoloGene: 8414 GeneCards: MBD1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • double-stranded methylated DNA binding • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • methyl-CpG binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • nuclear speck • nuclear matrix • Cromosom • cnewyllyn cell • nucleoplasm Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • transcription by RNA polymerase II • transcription, DNA-templated • GO:0045996 negative regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:1901227 negative regulation of transcription by RNA polymerase II • DNA methylation-dependent heterochromatin assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4152	n/a
Ensembl	ENSG00000141644	n/a
UniProt	Q9UIS9	n/a
RefSeq (mRNA)	NM_001204136 NM_001204137 NM_001204138 NM_001204139 NM_001204140 NM_001204141 NM_001204142 NM_001204143 NM_001204151 NM_002384 NM_015844 NM_015845 NM_015846 NM_015847 NM_001323942 NM_001323947 NM_001323949 NM_001323950 NM_001323951 NM_001323952 NM_001323953 NM_001323954	n/a
RefSeq (protein)	NP_001191065 NP_001191066 NP_001191067 NP_001191068 NP_001191069 NP_001191070 NP_001191071 NP_001191072 NP_001191080 NP_001310871 NP_001310876 NP_001310878 NP_001310879 NP_001310880 NP_001310881 NP_001310882 NP_001310883 NP_002375 NP_056669 NP_056670 NP_056671 NP_056723	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MBD1 yw MBD1 a elwir hefyd yn Methyl-CpG binding domain protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 18, band 18q21.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MBD1.

• RFT
• PCM1
• CXXC3

• "CpG dinucleotide positioning patterns determine the binding affinity of methyl-binding domain to nucleosomes. ". Biochim Biophys Acta. 2017. PMID 28377300.
• "Molecular dynamics study of the recognition of dimethylated CpG sites by MBD1 protein. ". J Chem Inf Model. 2015. PMID 25658035.
• "Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair. ". Int J Oncol. 2013. PMID 23588667.
• "Up-regulation of MBD1 promotes pancreatic cancer cell epithelial-mesenchymal transition and invasion by epigenetic down-regulation of E-cadherin. ". Curr Mol Med. 2013. PMID 23331011.
• "MeCP2: structure and function.". Biochem Cell Biol. 2011. PMID 21326358.